PKC and calcium channel trafficking
نویسندگان
چکیده
منابع مشابه
The long and short of PKC modulation of the L-type calcium channel
L-type calcium channel (LTCC) function is critical for electrical and cellular signaling in a diverse range of cell types. In cardiac muscle LTCC function (I Ca,L) provides trigger Ca 2+ for Ca2+-induced Ca release, and ICa,L kinetics is a critical determinant of action potential duration.1 LTCC blockade is an effective antihypertensive regimen, likely owing to contributions of ICa,L in vascula...
متن کاملRegulation of L-type calcium channel sparklet activity by c-Src and PKC-α.
The activity of persistent Ca²⁺ sparklets, which are characterized by longer and more frequent channel open events than low-activity sparklets, contributes substantially to steady-state Ca²⁺ entry under physiological conditions. Here, we addressed two questions related to the regulation of Ca²⁺ sparklets by PKC-α and c-Src, both of which increase whole cell Cav1.2 current: 1) Does c-Src activat...
متن کاملA simulation study of calcium release channel
The IP3R calcium release channel has been simulated using a stochastic simulation algorithm (SSA;Gillespie algorithm) and De young-Keiser model. A set of different concentration for Cat' and IP3 havebeen used. Considering the Number of molecules in each state, a non linear behavior of the system can beseen clearly. The inhibiting role of the Ca+2 on the open state (X110) has been studied. The d...
متن کاملLipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release.
Lysosomal lipid accumulation, defects in membrane trafficking and altered Ca(2+) homoeostasis are common features in many lysosomal storage diseases. Mucolipin transient receptor potential channel 1 (TRPML1) is the principle Ca(2+) channel in the lysosome. Here we show that TRPML1-mediated lysosomal Ca(2+) release, measured using a genetically encoded Ca(2+) indicator (GCaMP3) attached directly...
متن کاملTrafficking of neuronal calcium channels
Neuronal voltage-gated calcium channels (VGCCs) serve complex yet essential physiological functions via their pivotal role in translating electrical signals into intracellular calcium elevations and associated downstream signalling pathways. There are a number of regulatory mechanisms to ensure a dynamic control of the number of channels embedded in the plasma membrane, whereas alteration of th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Channels
سال: 2017
ISSN: 1933-6950,1933-6969
DOI: 10.1080/19336950.2017.1397924